王宪波主任医师_首都医科大学附属北京地坛医院_肝病科

xuanhujiaoyu

王宪波

王宪波,男,主任医师,教授,博士生导师,首都名中医,首都医科大学附属北京地坛医院中西医结合中心主任,国家中医药管理局中医传染病重点学科带头人,国家中医药管理局中医肝病重点专科负责人,北京市中西医结合肝病特色诊疗中心负责人,首批全国优秀中医临床人才,第七批全国老中医药专家学术经验继承工作指导老师。兼任评审专家、中国医师协会中西医结合医师分会肝病专家委员会第三届主任委员、中国民族医药学会传染病分会会长、中华中医药学会肝胆病分会第二届委员会副主任委员、中华中医药学会脾胃病专业委员会常委等。

姓名

王宪波

性别

民族

汉族

出生日期

1963年

临床职称

主任医师

教学职称

教授、博士生导师

毕业院校

上海中医药大学

诊治范围

在多年的临床实践中,擅长运用中医和中西医结合的方法治疗慢性肝炎、肝硬化、肝衰竭、肝癌、脂肪肝、乙型肝炎、丙型肝炎、病毒性肝炎、自身免疫性肝病等各种肝病。

教育经历

1980年9月-1985年7月,河北中医学院,学士

1987年9月-1990年7月,山东中医药大学,硕士研究生

1999年9月-2002年7月,上海中医药大学,博士研究生

工作经历

1985年7月-1987年8月,新乡医学院第一附属医院,医师

1990年7月-1995年11月,新乡医学院第一附属医院,主治医师

1995年12月-1999年8月,新乡医学院第一附属医院,副主任医师

2002年7月-2005年6月,上海中医药大学附属岳阳中西医结合医院,主任医师

2005年6月至今,首都医科大学附属北京地坛医院中西医结合中心,主任,主任医师

研究方向

中医药治疗重症肝病的临床和基础研究。

科研成果

1995年10月,“愈肝冲剂治疗慢性乙型肝炎的临床研究”获河南省科技进步奖三等奖。

2015年10月,“常见脾胃病中医诊疗专家共识意见”获中华中医药学会科学技术奖二等奖。

2016年10月,“解毒凉血健脾法提高慢加急性肝衰竭疗效的创新技术建立及推广应用”获北京市科学技术三等奖。

2017年,“解毒凉血健脾法提高慢加急性肝衰竭疗效的创新技术建立及推广应用”获中华医学会科技奖二等奖。

学术兼职

中国民族医药学会传染病分会会长

中国医师协会中西医结合医师分会肝病专家委员会主任委员

中华中医药学会肝胆病分会第二届委员会副主任委员

北京中西医结合学会感染病专业委员会副主任委员

中国民族医学学会肝病分会副会长

中国中西医结合学会传染病专业委员会委员

世界中医药联合会肝病专业委员会理事

中国中西医结合学会肝病专业委员会委员

北京市中医药学会感染病专业委员会副主任委员

北京中西医结合学会第一、二届传染病专业委员会主任委员

中华中医药学会脾胃病专业委员会常委

出版著作

《慢性肝炎合理用药》,主编,中国医药科技出版社,2009

《中西医结合传染病学》,副主编,中国中医药出版社,201210

主要论文

1. Jingyuan Liu#, Yuyong Jiang#, Yao Liu#, Lin Pu, Chunjing Du, Yuxin Li, Xiaojing Wang, Jie Ren, Wei Liu, Zhiyun Yang, Zhihai Chen, Rui Song*, Wen Xie*, Xianbo Wang*.Yindan Jiedu Granules, a Traditional Chinese Medicinal Formulation, as a Potential Treatment for Coronavirus Disease 2019.Front Pharmacol.2021.11.634266.SCI

2. Jingyuan Liu#, Yao Liu#, Pan Xiang, Lin Pu, Haofeng Xiong, Chuansheng Li, Ming Zhang, Jianbo Tan, Yanli Xu, Rui Song, Meihua Song, Lin Wang, Wei Zhang, Bing Han, Li Yang, Xiaojing Wang, Guiqin Zhou, Ting Zhang, Ben Li, Yanbin Wang*, Zhihai Chen*, Xianbo Wang*.Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage. Journal of Translational Medicine.2020.18(1).206.SCI

3. Yao Liu#, Yuxin Li#, Xiaojing Wang#, Yunyi Huang, Qun Zhang, Ke Shi, Chongping Ran, Jie Hou, Xianbo Wang*.Fufang Banmao Capsule, a Traditional Chinese Medicinal Formulation, Enhances the Survival of Patients with Hepatocellular Carcinoma and Vp3-4 Portal Vein Tumor Thrombosis Undergoing Supportive Treatment. Journal of Alternative and Complementary Medicine.2020.26(10).956-965.SCI

4. Ke Shi#, Yao Liu#, Xiaojing Wang#, Yuxin Li, Qun Zhang, Ying Hu, Chongping Ran, Yunyi Huang, Jie Hou, Xianbo Wang*.Adjuvant Fuzheng Huayu Capsule Reduces the Incidence of Hepatocellular Carcinoma in Patients with Hepatitis B-Caused Cirrhosis.Evid Based Complement Alternat Med.2020.2020.8826091.SCI

5. Yao Liu#, Ying Feng#, Yuxin Li#, Ying Hu, Qun Zhang, Yunyi Huang, Ke Shi, Chongping Ran, Jie Hou, Guiqin Zhou*, Xianbo Wang*.Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression. .Frontiers in Pharmacology.2020.11.867.SCI

6. Linghang Wang#,Yao Liu#,Ting Zhang#,Yuyong Jiang,Siyuan Yang,Yanli Xu,Rui Song,Meihua Song,Lin Wang,Wei Zhang,Bing Han,Li Yang,Ying Fan,Cheng Cheng,Jingjing Wang,Pan Xiang,Lin Pu,Haofeng Xiong,Chuansheng Li,Ming Zhang,Jianbo Tan,Zhihai Chen*,Jingyuan Liu*, Xianbo Wang*.Differentiating Between 2019 Novel Coronavirus Pneumonia and Influenza Using a Nonspecific Laboratory Marker-Based Dynamic Nomogram. Open Forum Infectious Diseases.2020.7(5).ofaa169.SCI

7. Yixin Hou, Qianqian Zhang, Fangyuan Gao, Dewen Mao, Jun Li, Zuojiong Gong, Xinla Luo, Guoliang Chen, Yong Li, Zhiyun Yang*, Kewei Sun*,Xianbo Wang*.Artificial neural network-based models used for predicting 28- and 90-day mortality of patients with hepatitis B-associated acute-on-chronic liver failure.BMC Gastroenterol.2020.20(1).75.SCI

8. Yao Liu#, Ying Feng#, Xiaojing Wang#, Xue Yang, Ying Hu, Yuxin Li, Qun Zhang, Yunyi Huang, Ke Shi, Chongping Ran, Jie Hou, Li Jiang*, Junfa Li*, Xianbo Wang*.SPARC Negatively Correlates With Prognosis After Transarterial Chemoembolization and Facilitates Proliferation and Metastasis of Hepatocellular Carcinoma via ERK/MMP Signaling Pathways.Frontiers in Oncology.2020.10.813.SCI

9. Yao Liu#, Yuxin Li#, Fangyuan Gao, Qun Zhang, Xue Yang, Bingbing Zhu, Shuaishuai Niu, Yunyi Huang, Ying Hu, Wei Li*, Xianbo Wang*.Comparison of transcatheter arterial chemoembolization-radiofrequency ablation and transcatheter arterial chemoembolization alone for advanced hepatocellular carcinoma with macrovascular invasion using propensity score analysis: a retrospective cohort study.Journal of Oncology.2020.2020.1341863.SCI

10. 王宪波*, 刘景院, 王晓静, 江宇泳, 李玉鑫.新型冠状病毒肺炎诊治实践与体会.北京中医药.2020.39(02).109-111.核心期刊

11. Huimin Liu#, Yuxin Li#, Fangyuan Gao, Peipei Meng, Hao Yu, Tong Wu, Yang Zhou, Yuyong Jiang*, Xianbo Wang*.Serum clusterin: a promising marker for hepatitis B virus related acute-on-chronic liver failure and assessing short-term prognosis.Dis Marker.2020.2020.8814841.SCI

12. Liu Y#, Xue D#, Zhang X, Gao F, Sun L, Yang X, Li Y, Zhang Q, Zhu B, Niu S, Huang Y, Hu Y, Wang X*.Nomogram for individualized prediction of hepatocellular carcinoma with portal vein tumor thrombosis on conservative treatment.BioMed Research International.2020.2020.1473718.SCI

13. Jiang D#, Wang J#, Zhao X, Li Y, Zhang Q, Song C, Zeng H*, Wang X*.Entecavir resistance mutations rtL180M/T184L/M204V combined with rtA200V lead to tenofovir resistance.Liver international.2020.40(1).83-91.SCI

14. Liu Y#, Xue D#, Tan S#, Zhang Q, Yang X, Li Y, Zhu B, Niu S, Jiang L*, Wang X*.Comparison of macrovascular invasion-free survival in early-intermediate hepatocellular carcinoma after different interventions: A propensity score-based analysis .Journal of Cancer.2019.10(17).4063-4071 .SCI

15. Gao F#, Zhang Q#, Liu Y#, Gong G, Mao D, Gong Z, Li J, Luo X, Li X, Chen G, Li Y, Zhao W, Wan G, Li H*, Sun K*, Wang X*.Nomogram prediction of individual prognosis of patients with acute-on-chronic hepatitis B liver failure.Dig Liver Dis.2019.51(3).425-433.SCI

16. 时 克,王 晓 静,王宪波*.金龙胶囊联合西医疗法治疗原发性肝癌效果的 Meta 分析.中西医结合肝病杂志.2019.35(11).2495-2501.核心期刊

17. 黄云义,王宪波*.肝硬化合并细菌性腹水患者30天内死亡预测模型的建立 .临床肝胆病杂志.2019.35(11).2472-2477.核心期刊

18. 王宪波*,王晓静.慢加急性肝衰竭中医内科临床诊疗指南.北京中医药 .2019.38(3).200-206.核心期刊

19. Liu YM, Zhu LL, Li R, Zhang JL, Yao SS, Zhou XB, Zeng H*, Wang XB*.Xijiao Dihuang decoction and Rehmannia glutinosa Libosch protect mice against lipopolysaccharide and tumor necrosis factor alpha induced acute liver failure.Chin J Integr Med.2019.25(6).446-453.SCI

20. Yixin Hou, Zhiyun Yang, Yuying Yang, Fangyuan Gao, Xiaoli Liu, Qun Zhang, Bingbing Zhu, Yuyong Jiang*, Xianbo Wang*.Serum-ascites albumin gradient: an independent predictor of esophageal variceal bleeding in cirrhosis patients with ascites.International Journal of Clinical and Experimental Medicine.2019.12(7).8645-8653 .SCI

21. 侯艺鑫, 李玉鑫, 杨 雪, 杨志云, 江宇泳, 王宪波*.清肝化痰活血方对大鼠非酒精性脂肪性肝炎的防治作用.中西医结合肝病杂志.2019.29(01).46-49+105.核心期刊

22. 王宪波*, 王晓静.慢加急性肝衰竭中医临床诊疗指南.临床肝胆病杂志.2019.35(3).494-503.核心期刊

23. 侯艺鑫,杨志云,杨玉英,江宇泳,王宪波*.理气健脾方预防乙型肝炎肝硬化合并重度食管胃底静脉曲张患者1年内出血的疗效评价.临床肝胆病杂志.2019.35(04).780-784.核心期刊

24. Liu Y, Zhang Q, Yang X, Li Y, Zhu B, Niu S, Huang Y, Hu Y, Wang X*.Effects of various interventions on the occurrence of macrovascular invasion of hepatocellular carcinoma after the baseline serum γ glutamyltransferase stratication.OncoTargets and Terapy .2019.12.1671-1679.SCI

25. Gu WY#, Xu BY#, Zheng X#, Chen J#, Wang XB#, Huang Y#, Gao YH, Meng ZJ, Qian ZP, Liu F, Lu XB, Shang J, Li H, Wang SY, Sun X*, Li H*.Acute-on-chronic Liver Failure in China: Rationale for Developing a Patient Registry and Baseline Characteristics.Am J Epidemiol.2018.187(9).1829-1839.SCI

26. Gao F#, Li X#, Wan G#, Li Y, Zhang Q, Liu Y, Liu H, Li H*, Wang X*.Development and external validation of a prognostic nomogram for acute decompensation of chronic hepatitis B cirrhosis .BMC Gastroenterology .2018.18(1).179.SCI

27. Liu Y, Sun L, Gao F, Yang X, Li Y, Zhang Q, Zhu B, Niu S, Huang Y, Hu Y, Feng Y*, Jiang Y*, Wang X*.A new scoring model predicting macroscopic vascular invasion of early-intermediate hepatocellular carcinoma .Medicine.2018.97(49).e13536.SCI

28. Chen J#, Xue D#, Gao F, Tao L, Li Y, Zhang Q, Wang R, Sun L, Yang X, Liu Y, Zhu B, Niu S, Wang X*.Influence factors and a predictive scoring model for measuring the biochemical response of primary biliary cholangitis to ursodeoxycholic acid treatment..Eur J Gastroenterol Hepatol.2018.30(11).1352-1360.SCI

29. Xianbo Wang*, Yuxin Li, Fangyuan Gao.Chronic hepatitis B: could a non-invasive scoring model help predict therapy outcomes?.Future Virology.2018.13(3).155–157.SCI

30. Gang Wan#, Fangyuan Gao#, Jialiang Chen#, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng*, Xianbo Wang*.Nomogram prediction of individual prognosis of patients with hepatocellular carcinoma.BMC Cancer.2017.17(1).91.SCI

31. Li X#, Gao F#, Liu H, Zhang H, Liu Y, Ye X, Geng M, Sun L, Wang R, Li Y, Jiang Y, Wang X, Zhou G, Yang Z, Li A, Zeng H, Wang X*.Lamivudine improves short-term outcome in hepatitis B virus-related acute-on-chronic liver failure patients with a high model for end-stage liver disease score.Eur J Gastroenterol Hepatol.2017. 29(1).1-9.SCI

32. Sun L#, Wang R#, Gao FY, Li YX, Geng MF, Chen JL, Ye XQ, Li XS, Yang X, Wan G, Yang ZY*, Wang XB*.Predictive value of serum gamma- glutamyltransferase levels in patients with hepatocellular carcinoma.Neoplasma.2017.64(3).444-452.SCI

33. Gao F#, Sun L#, Ye X#, Liu Y, Liu H, Geng M, Li X, Yang X, Li Y, Wang R, Chen J, Wan G, Jiang Y, Wang X*.Development and validation of a prognostic model for acute-on-chronic hepatitis B liver failure.European Journal of Gastroenterology&Hepatology.2017.29(6).669-678.SCI

34. Yang X, Ye X, Sun L, Gao F, Li Y, Ji X, Wang X, Feng Y*, Wang X*.Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.Oncotarget.2017.8(37).61118-61132.SCI

35. 冯颖, 王晓静, 周桂琴, 王宪波*.临床科研一体化的分层渐进式教学模式在中医传染病人才培养中的探索与思考.西北医学教育.2017.25(3).463-466.核心期刊

36. 王宪波*, 高方媛.慢加急性肝衰竭:东西方诊断和预后的差异.世界华人消化杂志.2017.25(21).1910-1920.核心期刊

37. Geng M#, Li Y#, Gao F, Sun L, Yang X, Wang R, Chen J, Zhang Q, Wan G, Wang X*.A scoring model predicts hepatitis B e antigen seroconversion in chronic hepatitis B patients treated with nucleos(t)ide analogues: real-world clinical practice.International Journal of Infectious Diseases.2017.62.18-25.SCI

38. 周桂琴, 钟启华, 王融冰, 董小冬, 李斌, 杨莉, 王宪波*.FIB_4指数对自身免疫性肝炎肝纤维化的诊断价值.临床肝胆病杂志.2017.33(8).1487-1491.核心期刊

39. Liu Y#, Zhu L#, Liang S, Yao S, Li R, Liu S, Ma Y, Zhou X, Zhang J, Zeng H*, Wang X*.Galactose protects hepatocytes against TNF-α-induced apoptosis by promoting activation of the NF-κB signaling pathway in acute liver failure..Laboratory Investigation.2015.95(5).504-514.SCI

40. Fang-Yuan Gao, Yao Liu, Xiao-Shu Li, Xie-Qiong Ye, Le Sun, Ming-Fan Geng, Rui Wang, Hui-Min Liu, Xiao-Bing Zhou, Li-Li Gu, Yan-Min Liu, Gang Wan, Xian-Bo Wang*.Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B.World Journal of Gastroenterology.2015.21(27).8373-8381.SCI

41. Ruijie Wan#, Huimin Liu#, Xianbo Wang*, Gang Wan, Xiaojing Wang, Guiqin Zhou, Yuyong Jiang, Fengxia Sun, Zhiyun Yang.Noninvasive predictive models of liver fibrosis in patients with chronic hepatitis B.International Journal of Clinical and Experimental Medicine.2015.8(1).961-71.SCI

42. Fangyuan Gao#, Xiaoshu Li#, Mingfan Geng#, Xieqiong Ye, Huimin Liu, Yao Liu, Gang Wan, Xianbo Wang*.Pretreatment neutrophil-lymphocyte ratio: An independent predictor of survival in patients with hepatocellular carcinoma.Medicine.2015.94(11).e639.SCI

43. 4. Xianbo Wang, Yanmin Liu, Yujuan Chang, Huimin Liu, Peng Wang.Diagnosis and treatment of a 16-year-old Chinese patient with concurrent hereditary hemochromatosis and Gilbert’s syndrome.European Journal of Medical Research.2014.19(51).1-5.SCI

44. Liu H#, Zhang H#, Wan G, Sang Y, Chang Y, Wang X*, Hui Z*.Neutrophi-lymphocyte ratio: a novel predictor for short-term prognosis in acute-on-chronic hepatitis B liver failure.J Viral Hepat.2014.21(7).499-507.SCI

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